The Boilermakers produced their highest point total in the series since 1998 and largest margin since 1969. Fletcher Loyer and Omer Mayer each contributed 18 points, with Loyer going 5 of 5 from the field, including four 3-pointers.
Lamar Wilkerson scored 18 of his 20 points in the second half for Indiana, which lost its second straight to a top-10 team. Purdue took control early with an 11-4 run to build a 26-14 lead and led wire to wire throughout the contest.