Head coach Cristian Chivu is considering lineup changes for the 'make or break' European showdown as Inter needs to overturn a 2-goal deficit to reach the Round of 16 following their 3-1 defeat in the first leg.
Darmian, who impressed in his only competitive start of the season against Bodo/Glimt last week when he narrowly missed scoring with a thunderous half-volley, could displace Henrique who started in Saturday's Serie A match against Lecce.