Curacao will have a new head coach in charge for their World Cup warm-up friendly against Scotland on 30 May after Dick Advocaat stood down for personal reasons.
The former Rangers manager had led the Caribbean island's team to the finals for the first time but will be replaced with fellow Dutchman Fred Rutten.
At 78, Advocaat would have become the oldest coach in World Cup finals history.
He had described leading the island with a population of around 150,000 to the World Cup as the "craziest thing" he had achieved in a managerial career spanning nearly four decades.
But Dutch media reported on Monday that he has stood down because of his daughter's health.
"I've always said family is above football," he said. "So this is a self-evident decision.
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"But, of course, that doesn't change the fact that I'm going to miss Curacao, the people there and my colleagues very much."
Advocaat, who also managed the Netherlands, Belgium, South Korea, PSV Eindhoven and Sunderland, spent two years as Curacao head coach.
Unbeaten over six games, they reached their first finals by topping their CONCACAF qualifying group ahead of Jamaica, Trinidad & Tobago and Bermuda.
Steve Clarke's Scots entertain Japan and Ivory Coast in March friendlies before Curacao visit Hampden for their final warm-up match before the summer finals in the Americas.
By then, the islanders will be led by 63-year-old former Netherlands defender Rutten, who has managed PSV Eindhoven, Anderlecht and Feyenoord.
He had most recently returned to PSV as assistant to Ruud van Nistelrooy and had a spell as caretaker after his fellow Dutchman's departure in 2023.
Rutten's side begin their World Cup campaign with a Group E match against Germany in Houston on 14 June and also face Ivory Coast and Ecuador.
The Scots begin their campaign the previous day against Haiti, with Brazil and Morocco the other sides in Group C.